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Original Title: How is the HPV16 susceptible to various clinical disinfectants?


Human Papillomavirus (HPV) is a sexually transmitted infection that is common in humans. There is very limited information regarding the infection. One of the concepts known to researchers is the fact that HPV may lead to the development of cervical and other forms of anogenital cancers in humans (Meyers et al, 2014). Considering the nature and the life cycle of the virus, it was initially difficult to conduct any research on them. This was because researchers were unable to produce the virus outside humans, who are its hosts(Meyers et al, 2014). However, with the development of technology, methods such as organotypic raft culture have been used to produce the viruses for research purposes.For this reason, the research was conducted to determine the susceptibility of the viruses to various clinical disinfectants. The major research question in the article was, “How susceptible to clinical disinfectants is the HPV16.”In addition, the research asked, “What are the effects of clinical disinfectants on the infectivity of HPV16?”


The researcher used authentic and recombinant HPV16 particles to test for susceptibility todisinfectants. The particles were subjected to incubation under 11 different types of clinical disinfectants. Similarly, the researcher added neutralizers to inactivate the solutions and disinfectants. After these steps, the respective changes in the abilities of the HPV16 ton infect were measured and compared to those of the untreated viruses. The progress of the research was approved by the Pennsylvania state University College of Medicine’s Institutional Review Board. The disinfectants used include ethanol, GTA, PAA-Silver, among many others(Meyers et al, 2014).


From the previous tests done on non-enveloped viruses, it was observed that HPV16 was the most resistant virus(Meyers et al, 2014). From the research, the quasivirion and native vironHPV16 portrayed similar characteristics in terms of their resistances to some of the clinical disinfectants. However, they showed their susceptibilities when they were subjected to low concentrations of PAA-Silver andtriple phenolic isopropanol(Meyers et al, 2014). Similarly, the study showed that quasivirions and authentic virus were resistant to ortho-phthalaldehyde and glut araldehyde(Meyers et al, 2014). However, they were susceptible to solutionswith high concentrations of PAA-silver and hypochlorite. All these observations were made on the basis of the calculations in table 1. For instance, the table shows that PAA-silver and hypochloric disinfectants,with 5.15 log10and4.86log10 reductions respectively,reduced the infectivity of HPV16 authentic viruses by more than 99.99%with a 5.15 log10 reduction. The effects of the other disinfectants were also represented in the table.

Figure 1 was used to show the effects of various disinfectants on the susceptibility of the virions. The findingswere on a bar graph. Finally, table 2 was used to show the disinfectants’ efficacy on the virions for a 24 hour period.


The researchers made an achievement by presenting their first findings on the susceptibility of the HPV16’ native virions to clinical disinfectants. The research revealed that clinical disinfectants, which are commonly used by the microbiology community,have no effects on the infectivity of HVP16 viruses(Meyers et al, 2014). It is, therefore, the role of the microbiology community to formulate policies that would determine the types of clinical disinfectants to be used for various applications.


From theresearch, one would urge the microbiology community to revise its policies regarding the use of certain disinfectants that pose no effects on the infectivity of HPV16 viruses. Therefore, one would take homethe message that there is a possibility that the transmission of HPV16 is non-sexual or fomite(Meyers et al, 2014), owing to the resistance they portray.




Meyers, J., Ryndock, E., Conway, M. J., Meyers, C., & Robison, R. (2014). Susceptibility ofhigh-risk human papillomavirus type 16 to clinical disinfectants. Journal of Antimicrobial Chemotherapy, dku006.

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